Microparticles in endothelial cell and vascular homeostasis: are they really noxious?
نویسندگان
چکیده
haematologica | 2009; 94(3) | 313 | Microparticles in endothelial cell and vascular homeostasis: are they really noxious? Olivier Morel, Florence Toti, Nicolas Morel and Jean-Marie Freyssinet Université de Strasbourg, Faculté de Médecine, Institut d’Hématologie et d’Immunologie, Strasbourg, Hôpitaux Universitaires de Strasbourg, Pôle de Cardiologie, Strasbourg, INSERM, U.770, Le Kremlin-Bicêtre, Université Paris-Sud 11, Faculté de Médecine, Le Kremlin-Bicêtre, Département de Réanimation des Urgences, Hôpital Pellegrin, Bordeaux, France. E-mail: [email protected]. doi: 10.3324/haematol.2008.003657
منابع مشابه
The many faces of endothelial microparticles.
Endothelial microparticles (EMP) are complex vesicular structures shed from activated or apoptotic endothelial cells. They play a remarkable role in coagulation, inflammation, endothelial function, and angiogenesis and thus disturb the vascular homeostasis, contributing to the progression of vascular diseases. As a cause or a consequence, elevated levels of EMP were found in plasma from patient...
متن کاملMicroparticles in Angiogenesis: Therapeutic Potential Formation, Fate, and Function of Platelet Microparticles Microparticles in Vascular Function and Atherothrombosis Leukocyte-Derived Microparticles in Vascular Homeostasis
Considered during the past decades as cell dust, microparticles are now deemed true biomarkers and vectors of biological information between cells. Depending on their origin, the composition of microparticles varies and the subsequent message transported by them, such as proteins, mRNA, or miRNA, can differ. Recent studies have described microparticles as “cargos” of deleterious information in ...
متن کاملMicroparticles: Protagonists of a Novel Communication Network for Intercellular Information Exchange Formation, Fate, and Function of Platelet Microparticles Microparticles in Coagulation and Thrombosis Microparticles in Angiogenesis: Therapeutic Potential Microparticles in Vascular Function and Atherothrombosis Leukocyte-Derived Microparticles in Vascular Homeostasis
Leukocyte-derived microparticles (LMPs) may originate from neutrophils, monocytes/macrophages, and lymphocytes. They express markers from their parental cells and harbor membrane and cytoplasmic proteins as well as bioactive lipids implicated in a variety of mechanisms, maintaining or disrupting vascular homeostasis. When they carry tissue factor or coagulation inhibitors, they participate in h...
متن کاملCell-derived microparticles in the pathogenesis of cardiovascular disease: friend or foe?
Microparticles are ascribed important roles in coagulation, inflammation, and endothelial function. These processes are mandatory to safeguard the integrity of the organism, and their derangements contribute to the development of atherosclerosis and cardiovascular disease. More recently, the presumed solely harmful role of microparticles has been challenged because microparticles may also be in...
متن کاملMicroparticles in Hemostasis and Thrombosis Microparticles in Angiogenesis: Therapeutic Potential Formation, Fate, and Function of Platelet Microparticles Microparticles in Vascular Function and Atherothrombosis Leukocyte-Derived Microparticles in Vascular Homeostasis
Blood contains microparticles (MPs) derived from a variety of cell types, including platelets, monocytes, and endothelial cells. In addition, tumors release MPs into the circulation. MPs are formed from membrane blebs that are released from the cell surface by proteolytic cleavage of the cytoskeleton. All MPs are procoagulant because they provide a membrane surface for the assembly of component...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Haematologica
دوره 94 3 شماره
صفحات -
تاریخ انتشار 2009